Exosome Biogenesis & IDP Spreading

We study how exosomes and other EVs form, sort cargo, and disseminate intrinsically disordered/amyloid‑prone proteins across tissues. Light‑driven microfluidic isolation of EV subpopulations enables molecular mapping of IDP packaging, release, and uptake.

We examine endosomal budding and MVB‑plasma membrane fusion, testing how lipid composition (PIP2/DAG) and scaffolds bias IDP sorting and exosome release.

Photocleavable ‘nano‑probe’ workflows isolate size‑/marker‑defined EVs with gentle release for proteomics/lipidomics and functional seeding assays.

Selected publications

Photosensitive nanoprobes for EV subpopulation isolation. Advanced Functional Materials, 2024 (Cover). See publications →
Programmable light‑driven fractionation of extracellular, cell‑membrane, and biomimetic vesicles. Advanced Materials, in review. See publications →
Lipid‑vesicle native mass spectrometry of membrane assemblies. Nature Methods, 2023 (Cover). See publications →